ELISA Phospho-SP1 (Thr739) anti-

Quantity :100µL Clone Number: Aliases:SP 1 antibody; SP1 antibody; Sp1 transcription factor antibody; SP1_ antibody; Specificity protein 1 antibody; Transcription factor Sp1 antibody; TSFP 1 antibody; TSFP1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P08047 Immunogen:Peptide sequence around phosphorylation site of threonine 739 (T-A-T(p)-P-S) derived from SP1 Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Transcription factor that can activate or repress transcription in response to physiological and pathological stimµLi. Binds with high affinity to GC-rich motifs and regµLates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regµLated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-a G-box promoter. May have a role in modµLating the cellµLar response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regµLation of FE65 gene expression. Thiesen HJ,et al.(1990)Nucleic Acids Res.18(11):3203-9. Zutter MM,et al.(1997) Blood.90(2):678-89. Lou Z,et al.(2005)Cancer Res.65(3):1007-17 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SP1 Research Areas:Epigenetics and Nuclear Signaling;Metabolism;Stem cells