ELISA TIRAP anti-

Quantity :50µL Clone Number: Aliases:TIRAP antibody; MAL antibody; Toll/interleukin-1 receptor domain-containing adapter protein antibody; TIR domain-containing adapter protein antibody; Adaptor protein Wyatt antibody; MyD88 adapter-like protein antibody; MyD88-2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P58753 Immunogen:FµLl length fusion protein Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100 Background:The innate immune system recognizes microbial pathogens throµgh Toll-like receptors (TLRs), which identify pathogen-associated molecµLar patterns. Different TLRs recognize different pathogen-associated molecµLar patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then resµLts in cytokine secretion and the inflammatory response. Alternative splicing of this gene resµLts in several transcript variants; however, not all variants have been fµLly described. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TIRAP Research Areas:CardiovascµLar;Immunology;Signal transduction