ELISA ZRANB3 Antibody, HRP

Quantity :50µg Clone Number: Aliases:4933425L19Rik antibody; AH2 antibody; Annealing helicase 2 antibody; DNA annealing helicase and endonuclease ZRANB3 antibody; MGC105033 antibody; MGC75012 antibody; OTTHUMP00000197449 antibody; Zinc finger Ran-binding domain-containing protein 3 antibody; Zinc finger; RAN- binding domain containing 3 antibody; ZRAB3_ antibody; Zranb3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q5FWF4 Immunogen:Recombinant DNA annealing helicase and endonuclease ZRANB3 protein (370-624AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that coµLd occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3\\\'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ZRANB3 Research Areas:Epigenetics and Nuclear Signaling