ELISA TH (Ab-31) anti-

Quantity :100µL Clone Number: Aliases:Dystonia 14 antibody; DYT14 antibody; DYT5b antibody; EC 1.14.16.2 antibody; OTTHUMP00000011225 antibody; OTTHUMP00000011226 antibody; ple antibody; Protein Pale antibody; TH antibody; The antibody; TY3H_ antibody; TYH antibody; Tyrosine 3 hydroxylase antibody; Tyrosine 3 monooxygenase antibody; Tyrosine 3-hydroxylase antibody; Tyrosine 3-monooxygenase antibody; Tyrosine hydroxylase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P07101 Immunogen:Peptide sequence around aa.29~33(V-T-S-P-R)derived from Mouse Tyrosine Hydroxylase. Raised in:Rabbit Reactivity:Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regµLatory and catalytic domain, and exists in several different isoforms This enzyme is required for embryonic development since TH knockout mice die before or at birth Levels of transcription, translation and posttranslational modification regµLate TH activity. The amino-terminal regµLatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regµLates the catalytic activity of TH Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH throµgh stabilization of TH protein levels. Kumer, S.C. and Vrana, K.E. (1996) J Neurochem 67, 443-62. Bodeau-P Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TH Research Areas:Neuroscience?Cancer;Metabolism