ELISA VPS26B anti-

Quantity :50µg Clone Number: Aliases:Pep8b antibody; Vacuolar protein sorting 26 homolog B (S. pombe) antibody; Vacuolar protein sorting 26 homolog B (yeast) antibody; Vacuolar protein sorting-associated protein 26B antibody; Vesicle protein sorting 26B antibody; VP26B_ antibody; VPS26B antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q4G0F5 Immunogen:Recombinant Vacuolar protein sorting-associated protein 26B protein (1-336AA) Raised in:Rabbit Reactivity:, Rat, Mouse Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:VPS26B Research Areas:Others