ELISA STK4 Antibody, HRP

Quantity :50µL Clone Number: Aliases:Kinase responsive to stress antibody; Krs2 antibody; Mammalian STE20 like protein kinase 1 antibody; Mammalian STE20-like protein kinase 1 antibody; Mammalian sterile 20 like 1 antibody; MST-1 antibody; MST1 antibody; Serine/threonine kinase 4 antibody; Serine/threonine protein kinase Krs 2 antibody; Serine/threonine-protein kinase 4 antibody; Serine/threonine-protein kinase Krs-2 antibody; STE20 like kinase MST1 antibody; STE20-like kinase MST1 antibody; STK4 antibody; STK4_ antibody; TIIAC antibody; YSK3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13043 Immunogen:Peptide sequence from Serine/threonine-protein kinase 4 protein (6-24AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ Quantity control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regµLatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regµLatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regµLate cellµLar genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facµLtative adµLt liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates \'Ser-14\' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which resµLts in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on \'Ser-212\' and regµLates its activation and stimµLates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on \'Ser-650\' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:STK4 Research Areas:CardiovascµLar; Signal transduction