ELISA DOCK1 anti-

Quantity :50µg Clone Number: Aliases:180 kDa protein downstream of CRK antibody; Ced5 antibody; Dedicator of Cytokinesis 1 antibody; Dedicator of cytokinesis protein 1 antibody; DOCK 1 antibody; DOCK 180 antibody; DOCK1 antibody; DOCK1_ antibody; DOCK180 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q14185 Immunogen:Recombinant Dedicator of cytokinesis protein 1 protein (1676-1865AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regµLation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DOCK1 Research Areas:Cancer; Cell biology; Metabolism; Signal transduction