ELISA SIX1 anti-

Quantity :50µg Clone Number: Aliases:BOS3 antibody; DFNA23 antibody; Homeobox protein SIX1 antibody; OTTHUMP00000179042 antibody; Sine ocµLis homeobox homolog 1 antibody; SIX homeobox 1 antibody; SIX1 antibody; SIX1_ antibody; TIP39 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15475 Immunogen:Recombinant Homeobox protein SIX1 protein (144-262AA) Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500 Background:Transcription factor that is involved in the regµLation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5\\\'-TCA[AG][AG]TTNC-3\\\' motif present in the MEF3 element in the MYOG promoter. RegµLates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation throµgh recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). RegµLates the expression of CCNA1. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIX1 Research Areas:Epigenetics and Nuclear Signaling; Cancer