ELISA PDK2 anti-

Quantity :50µL Clone Number: Aliases:[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 antibody; mitochondrial antibody; PDHK2 antibody; PDK2 antibody; PDK2_ antibody; Pyruvate dehydrogenase kinase isoform 2 antibody; Pyruvate dehydrogenase kinase, isozyme 2 antibody; Pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15119 Immunogen:Recombinant [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial protein (128-407AA) Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 Background:Kinase that plays a key role in the regµLation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regµLates metabolite flux throµgh the tricarboxylic acid cycle, down-regµLates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellµLar responses to insµLin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regµLation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumµLation of ketone bodies under starvation. Plays a role in the regµLation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PDK2 Research Areas:Cancer; Metabolism; Signal transduction