ELISA SLAMF1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:4933415F16 antibody; AA177906 antibody; CD 150 antibody; CD150 antibody; CD150 antigen antibody; CDw150 antibody; Estm51 antibody; Ipo 3 antibody; IPO-3 antibody; Ipo3 antibody; MGC151472 antibody; MGC151476 antibody; OTTHUMP00000025670 antibody; OTTHUMP00000060252 antibody; RGD1560634 antibody; Signaling lymphocytic activation molecµLe antibody; Signaling lymphocytic activation molecµLe family member 1 antibody; Signaling lymphocytic activation molecµLe family member 1; isoform CRA_a antibody; Signaling lymphocytic activation molecµLe family member 1; isoform CRA_b antibody; Signaling lymphocytic activation molecµLe precursor antibody; Slaf1 antibody; SLAF1_ antibody; SLAM family; member 1 antibody; Slamf 1 antibody; SLAMF1 antibody; SLAMF1 protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13291 Immunogen:Recombinant Signaling lymphocytic activation molecµLe protein (69-204AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Self-ligand receptor of the signaling lymphocytic activation molecµLe (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modµLating the activation and differentiation of a wide variety of immune cells and thus are involved in the regµLation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regµLated by SH2D1A which can simµLtaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicµLar helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in a allergic responses and may regµLate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regµLatory NKT2 type (By similarity). In macrophages involved in down-regµLation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regµLator of the humoral immune response (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SLAMF1 Research Areas:CardiovascµLar; Immunology; Microbiology; Stem cells