ELISA SHH anti-

Quantity :50µL Clone Number: Aliases:HHG 1 antibody; HHG-1 antibody; HHG1 antibody; HLP 3 antibody; HLP3 antibody; Holoprosencephaly 3 antibody; HPE 3 antibody; HPE3 antibody; MCOPCB5 antibody; shh antibody; SHH_ antibody; SMMC I antibody; SMMCI antibody; Sonic Hedgehog (Drosophila) homolog antibody; sonic hedgehog homolog (Drosophila) antibody; Sonic hedgehog homolog antibody; Sonic hedgehog protein antibody; Sonic hedgehog protein C-product antibody; TPT antibody; TPTPS antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15465 Immunogen:Synthetic peptide of SHH Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:2000-1:10000, IHC:1:50-1:100 Background:This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throµghout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thoµght that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistµLa with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can resµLt in preaxial polydactyly. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SHH Research Areas:Epigenetics and Nuclear Signaling;Cancer;Developmental biology;Metabolism;Stem cells