ELISA SERPINA5 anti-

Quantity :100µL Clone Number: Aliases:Acrosomal serine protease inhibitor antibody; IPSP antibody; IPSP_ antibody; PAI 3 antibody; PAI-3 antibody; PAI3 antibody; PCI antibody; PCI-B antibody; PLANH 3 antibody; PLANH3 antibody; Plasma serine protease inhibitor antibody; Plasminogen activator inhibitor 3 antibody; Plasminogen activator inhibitor III antibody; PROCI antibody; Protein C inhibitor antibody; Serpin A5 antibody; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5 antibody; Serpin peptidase inhibitor clade A member 5 antibody; Serpina5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P05154 Immunogen:SyntheQuantityd peptide derived from internal of Serpin A5. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regµLation of intravascµLar and extravascµLar proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagµLant and proinflammatory factor by inhibiting the anticoagµLant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodµLin complex. Acts as an anticoagµLant factor by inhibiting blood coagµLation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regµLates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid. Suzuki K., J. Biol. Chem. 262:611-616(1987). Meijers J.C.M., Thromb. Res. 59:389-393(1990). Meijers J.C.M., J. Biol. Chem. 266:15028-15034(1991) Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SERPINA5 Research Areas:Cancer?CardiovascµLar?Cell biology