ELISA TSC2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:FLJ43106 antibody; LAM antibody; OTTHUMP00000158940 antibody; OTTHUMP00000198394 antibody; OTTHUMP00000198395 antibody; PPP1R160 antibody; Protein phosphatase 1; regµLatory subunit 160 antibody; TSC complex subunit 2 antibody; tsc2 antibody; TSC2_ antibody; TSC4 antibody; TSC4 gene; formerly antibody; TSC4; formerly antibody; Tuberin antibody; Tuberous sclerosis 2 antibody; Tuberous sclerosis 2 protein antibody; Tuberous sclerosis 2 protein homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P49815 Immunogen:Recombinant Tuberin protein (1396-1496AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimµLated phosphorylation of S6K1 and EIF4EBP1 by negatively regµLating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubµLe-mediated protein transport. Also stimµLates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TSC2 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism; Signal transduction