ELISA TNR anti-

Quantity :50µg Clone Number: Aliases:Janusin antibody; MGC149328 antibody; Restrictin antibody; Tenascin R (restrictin, janusin) antibody; Tenascin-R antibody; TENR_ antibody; TN-R antibody; Tnr antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92752 Immunogen:Recombinant Tenascin-R protein (1231-1319AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:500-1:1000 Background:Neural extracellµLar matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellµLar behavior by either evoking a stable adhesion and differentiation, or repµLsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and resµLts in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sµLfatides resµLts in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repµLsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regµLation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sµLfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regµLated addition of sµLfated carbohydrate structure may modµLate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TNR Research Areas:Neuroscience; Developmental biology; Signal transduction