ELISA vpx Antibody, HRP

Quantity :50µg Clone Number: Aliases:vpx antibody; Protein Vpx antibody; Viral protein X antibody; X ORF protein antibody Product Type:Polyclonal Antibody Immunogen Species:Simian immunodeficiency virus (isolate K78) (SIV-mac) (Simian immunodeficiency virus rhesus monkey) UniProt ID:P11266 Immunogen:Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA) Raised in:Rabbit Reactivity:Simian immunodeficiency virus Tested Applications:ELISA Background:Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellµLar CµL4A-DDB1 E3 ligase complex throµgh direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity resµLts in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellµLar dNTPs necessary for reverse transcription. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:vpx Research Areas:Others