ELISA botA Antibody, Biotin

Quantity :50µg Clone Number: Aliases:botA antibody; atx antibody; bonTBotµLinum neurotoxin type A antibody; BoNT/A antibody; Bontoxilysin-A antibody; BOTOX antibody; BotµLinum neurotoxin type A1) [Cleaved into: BotµLinum neurotoxin A light chain antibody; LC antibody; EC 3.4.24.69); BotµLinum neurotoxin A heavy chain antibody; HC)] antibody Product Type:Polyclonal Antibody Immunogen Species:Clostridium botµLinum UniProt ID:P0DPI0 Immunogen:Recombinant Clostridium botµLinum BotµLinum neurotoxin type A protein (1-436AA) Raised in:Rabbit Reactivity:Clostridium botµLinum Tested Applications:ELISA Background:Inhibits acetylcholine release. The botµLinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release resµLts in flaccid paralysis, with frequent heart or respiratory failure. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:botA Research Areas:Others