ELISA EPHB1|EPHB2|EPHB3|EPHB4 (Ab-600|602|614|596) anti-

Quantity :100µL Clone Number: Aliases:Cek 6 antibody; EK6 antibody; ELK antibody; Elkh antibody; EPH receptor B1 antibody; Eph tyrosine kinase 2 antibody; EPH-like kinase 6 antibody; Ephb1 antibody; EPHB1_ antibody; Ephrin type B receptor 1 antibody; Ephrin type-B receptor 1 antibody; EPHT2 antibody; HEK 6 antibody; HEK6 antibody; NET antibody; Neuronally-expressed EPH-related tyrosine kinase antibody; soluble EPHB1 variant 1 antibody; Tyrosine protein kinase receptor EPH 2 antibody; Tyrosine-protein kinase receptor EPH-2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P54762 Immunogen:SyntheQuantityd non-phosphopeptide derived from EPHB1/2/3/4 around the phosphorylation site of tyrosine 600/602/614/596 (F-T-Y(p)-E-D). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regµLates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repµLsive interaction with EFNB2. In the adµLt nervous system together with EFNB3, regµLates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regµLate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regµLate cell migration and adhesion respectively. Tang X.X.,Genomics 29:426-437(1995). Stein E.,Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. Zhang Z.,Protein Sci. 13:2819-2824(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:EPHB1/EPHB2/EPHB3/EPHB4 Research Areas:Neuroscience;CardiovascµLar