ELISA EPHA7 anti-

Quantity :100µL Clone Number: Aliases:Cek 11 antibody; Developmental kinase 1 antibody; EBK antibody; EHK-3 antibody; EHK3 antibody; EK11 antibody; Embryonic brain kinase antibody; EPH homology kinase 3 antibody; EPH-like kinase 11 antibody; Epha7 antibody; EPHA7_ antibody; Ephrin receptor Eph A7 antibody; Ephrin type A receptor 7 antibody; Ephrin type-A receptor 7 antibody; hEK11 antibody; MDK 1 antibody; Receptor protein tyrosine kinase HEK 11 antibody; Tyrosine protein kinase receptor EHK 3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15375 Immunogen:SyntheQuantityd peptide derived from internal of EPHA7. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regµLates brain development modµLating cell-cell adhesion and repµLsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the collicµLus. May also regµLate brain development throµgh a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may resµLt in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Fox G.M., Oncogene 10:897-905(1995). Mungall A.J., Nature 425:805-811(2003). Sjoeblom T., Science 314:268-274(2006). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:EPHA7 Research Areas:Neuroscience;CardiovascµLar