ELISA SHC1 (Ab-349) anti-

Quantity :100µL Clone Number: Aliases:FLJ26504 antibody; p66 antibody; p66SHC antibody; SH2 domain protein C1 antibody; SHC (Src homology 2 domain containing) transforming protein 1 antibody; SHC 1 antibody; SHC A antibody; SHC adaptor protein 1 antibody; Shc antibody; SHC transforming protein 1 antibody; SHC transforming protein antibody; SHC-transforming protein 1 antibody; SHC-transforming protein 3 antibody; SHC-transforming protein A antibody; SHC1 antibody; SHC1_ antibody; SHCA antibody; Src homology 2 domain-containing-transforming protein C1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P29353 Immunogen:Peptide sequence around aa.347~351 (H-Q-Y-Y-N) derived from Shc1. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IF; WB:1:500-1:1000, IF:1:100-1:200 Background:Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regµLate the cellµLar response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellµLar oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span Trampont P, et al. (2006) Mol Cell Biol; 26(23): 9035-9044. Patrussi L, et al. (2005) Oncogene; 24(13): 2218-2228 van der Geer P, et al. (1996) Curr Biol ; 6(11): 1435-1444 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SHC1 Research Areas:Neuroscience;Signal transduction