ELISA TLR3 anti-

Quantity :50µL Clone Number: Aliases:CD283 antibody; CD283 antigen antibody; IIAE2 antibody; TLR 3 antibody; Tlr3 antibody; TLR3_ antibody; Toll Like Receptor 3 antibody; Toll-like receptor 3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15455 Immunogen:Fusion protein of TLR3 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; ELISA:1:2000-1:5000, WB:1:500-1:2000 Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to s and share structural and functional similarities. They recognize pathogen-associated molecµLar patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopµLation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TLR3 Research Areas:Immunology;Microbiology?Signal transduction