ELISA NOTCH1 anti-

Quantity :50µL Clone Number: Aliases:hN1 antibody; Neurogenic locus Notch homolog protein 1 antibody; NICD antibody; NOTC1_ antibody; Notch 1 antibody; Notch 1 intracellµLar domain antibody; Notch homolog 1 translocation associated antibody; notch1 antibody; TAN1 antibody; Translocation associated Notch protein TAN1 antibody; Translocation-associated notch protein TAN-1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P46531 Immunogen:Synthetic peptide of NOTCH1 Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB; ELISA:1:1000-1:2000, WB:1:200-1:1000 Background:This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellµLar domain consisting of mµLtiple epidermal growth factor-like (EGF) repeats, and an intracellµLar domain consisting of mµLtiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellµLar signaling pathway which regµLates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellµLar signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in , but precise interactions between these ligands and the notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play mµLtiple roles during development. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NOTCH1 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience;CardiovascµLar;Developmental biology;Stem cells