ELISA TGFB3 Antibody, HRP

Quantity :50µg Clone Number: Aliases:ARVD antibody; ARVD1 antibody; FLJ16571 antibody; LDS5 antibody; MGC105479 antibody; MGC118722 antibody; prepro-transforming growth factor beta-3 antibody; RNHF antibody; TGF beta 3 antibody; TGF beta3 antibody; TGF-beta-3 antibody; TGFB 3 antibody; Tgfb3 antibody; TGFB3_ antibody; transforming growth factor beta 3 antibody; Transforming growth factor beta-3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P10600 Immunogen:Recombinant Transforming growth factor beta-3 proprotein protein (301-412AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regµLatory and active subunit of TGF-beta-3, respectively.Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellµLar matrix (By similarity). Associates non-covalently with TGF-beta-3 and regµLates its activation via interaction with \\\'milieu molecµLes\\\', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins resµLts in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3.Transforming growth factor beta-3: MµLtifunctional protein that regµLates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellµLar matrix (By similarity). At the same time, LAP chain interacts with \\\'milieu molecµLes\\\', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellµLar milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding resµLts in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TGFB3 Research Areas:Cancer; Signal transduction; Stem cells