ELISA VASP (Ab-157) anti-

Quantity :100µL Clone Number: Aliases:Vasodilator stimµLated phosphoprotein antibody; Vasodilator-stimµLated phosphoprotein antibody; VASP antibody; VASP_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P50552 Immunogen:Peptide sequence around aa.155~159 (R-V-S-N-A) derived from VASP. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IF; WB:1:500-1:1000, IF:1:100-1:200 Background: Vasodilator-stimµLated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellµLar signaling pathways that regµLate integrin-extracellµLar matrix interactions. VASP is regµLated by the cyclic nucleotide-dependent kinases PKA and PKG. Zhao WM, et al. (2001) EMBO J 20(9): 2315-2325. Millard TH, et al. (2005) EMBO J 24(2): 240-250. K Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:VASP Research Areas:Signal transduction