ELISA Tp53 anti-

Quantity :50µg Clone Number: Aliases:Tp53 antibody; P53 antibody; CellµLar tumor antigen p53 antibody; Tumor suppressor p53 antibody Product Type:Polyclonal Antibody Immunogen Species:Rattus norvegicus (Rat) UniProt ID:P10361 Immunogen:Recombinant Rat CellµLar tumor antigen p53 protein (1-391AA) Raised in:Rabbit Reactivity:Rat, Mouse Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000 Background:Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regµLation as a trans-activator that acts to negatively regµLate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimµLation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression By similarity. Interacts with GRK5 Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Tp53 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology