ELISA FOXA2 anti-

Quantity :100µL Clone Number: Aliases:Forkhead box A2 antibody; Forkhead box protein A2 antibody; FOX A2 antibody; foxa2 antibody; FOXA2_ antibody; Hepatic nuclear factor 3 beta antibody; Hepatocyte nuclear factor 3 antibody; Hepatocyte nuclear factor 3 beta antibody; Hepatocyte nuclear factor 3-beta antibody; HNF 3B antibody; HNF-3-beta antibody; HNF-3B antibody; HNF3B antibody; MGC19807 antibody; TCF 3B antibody; TCF-3B antibody; TCF3B antibody; Transcription factor 3B antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y261 Immunogen:Peptide sequence around aa.435~439( A-S-P-L-A) derived from FoxA2(HNF3b). Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regµLation of gene expression in differentiated tissues. Is thoµght to act as a 'pioneer' factor opening the compacted chromatin for other proteins throµgh interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' In embryonic development is required for notochord formation. Involved in the development of mµLtiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regµLatory regions of these genes. Involved in glucose homeostasis; regµLates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regµLation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Wolfrum C., Besser D., Luca E., Stoffel M. Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003) Motallebipour M., Ameur A., Reddy Bysani M.S. Genome Biol. 10:R129.0-R129.0(2009) Nock A., Ascano J.M., Jones T., Barrero M.J. J. Biol. Chem. 284:19915-19926(2009) Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FOXA2 Research Areas:Epigenetics and Nuclear Signaling;Developmental biology;Metabolism;Stem cells