ELISA SGOL1 anti-

Quantity :100µL Clone Number: Aliases:hSgo 1 antibody; hSgo1 antibody; NY BR 85 antibody; Serologically defined breast cancer antigen NY BR 85 antibody; Serologically defined breast cancer antigen NY-BR-85 antibody; SGO 1 antibody; SGO antibody; SGO L1 antibody; SGO1 antibody; SGOL 1 antibody; SGOL1 antibody; SGOL1_ antibody; Shµgoshin 1AB protein antibody; Shµgoshin 1CD protein antibody; Shµgoshin 1EFprotein antibody; Shµgoshin 1GH protein antibody; Shµgoshin 1KL protein antibody; Shµgoshin like 1 (S. pombe) antibody; Shµgoshin like 1 antibody; Shµgoshin-like 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q5FBB7 Immunogen:SyntheQuantityd peptide derived from internal of SGOL1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubµLe to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regµLating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. McGuinness B.E., PLoS Biol. 3:433-449(2005). Kitajima T.S., Curr. Biol. 15:353-359(2005). Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SGO1 Research Areas:Epigenetics and Nuclear Signaling