ELISA POLR3H anti-

Quantity :100µL Clone Number: Aliases:POLR3H antibody; KIAA1665 antibody; RPC8 antibody; DNA-directed RNA polymerase III subunit RPC8 antibody; RNA polymerase III subunit C8 antibody; DNA-directed RNA polymerase III subunit H antibody; RNA polymerase III subunit 22.9 kDa subunit antibody; RPC22.9 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y535 Immunogen:SyntheQuantityd peptide derived from internal of RPC8. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which syntheQuantitys small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellµLar bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B throµgh the RIG-I pathway By similarity. Hu P., Mol. Cell. Biol. 22:8044-8055(2002). Hirosawa M., DNA Res. 8:1-9(2001). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:POLR3H Research Areas:Epigenetics and Nuclear Signaling