ELISA PPP4R2 anti-

Quantity :100µL Clone Number: Aliases:BE691708 antibody; C230060M08Rik antibody; MGC131930 antibody; PP4R2 antibody; PP4R2_ antibody; PPP4R2 antibody; protein phosphatase 4, regµLatory subunit 2 antibody; Serine/threonine protein phosphatase 4 regµLatory subunit 2 antibody; Serine/threonine-protein phosphatase 4 regµLatory subunit 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NY27 Immunogen:SyntheQuantityd peptide derived from internal of PP4R2. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:RegµLatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regµLate the activity of PPP4C at centrosomal microtubµLe organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, sµggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. Hastie C.J., Biochem. J. 347:845-855(2000). Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PPP4R2 Research Areas:Epigenetics and Nuclear Signaling;Tags & Cell Markers;Signal transduction