ELISA Phospho-TCF3 (Thr355) anti-

Quantity :100µL Clone Number: Aliases:AGM8 antibody; bHLHb21 antibody; Class B basic helix-loop-helix protein 21 antibody; E12 antibody; E2A antibody; E2A immunoglobµLin enhancer binding factors E12/E47 antibody; E47 antibody; Helix loop helix protein HE47 antibody; ImmunoglobµLin enhancer-binding factor E12/E47 antibody; ImmunoglobµLin transcription factor 1 antibody; ITF1 antibody; Kappa-E2-binding factor antibody; MGC129647 antibody; MGC129648 antibody; Negative vitamin D response element binding protein antibody; NOL1-TCF3 fusion antibody; TCF-3 antibody; Tcf3 antibody; TFE2_ antibody; transcription factor 3 (E2A immunoglobµLin enhancer binding factors E12/E47) antibody; Transcription factor 3 antibody; transcription factor 3 variant 3 antibody; Transcription factor E2-alpha antibody; Transcription factor ITF-1 antibody; VDIR antibody; VDR interacting repressor antibody; vitamin D receptor-interacting repressor antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P15923 Immunogen:Peptide sequence around phosphorylation site of threonine 355 (P-S-T(p)-P-V) derived from E2A Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; IHC:1:50-1:100 Background: E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobµLin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced isoforms have been described. Kamps M.P., Cell 60:547-555(1990). Nourse J., Cell 60:535-545(1990). Grimwood J., Nature 428:529-535(2004). Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TCF3 Research Areas:Epigenetics and Nuclear Signaling;Stem cells