ELISA TERT Antibody, HRP

Quantity :50µg Clone Number: Aliases:CMM9 antibody; DKCA2 antibody; DKCB4 antibody; EST2 antibody; HEST2 antibody; htert antibody; hTRT antibody; PFBMFT1 antibody; TCS1 antibody; Telomerase associated protein 2 antibody; Telomerase catalytic subunit antibody; Telomerase reverse transcriptase antibody; Telomerase-associated protein 2 antibody; Telomere Reverse Transcriptase antibody; TERT antibody; TERT_ antibody; TP2 antibody; TRT antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14746 Immunogen:Recombinant Telomerase reverse transcriptase protein (281-436AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regµLated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. ModµLates Wnt signaling. Plays important roles in aging and antiapoptosis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TERT Research Areas:Epigenetics and Nuclear Signaling; Cancer; Developmental biology; Stem cells