ELISA STAT5B anti-

Quantity :50µL Clone Number: Aliases:Signal transducer and activator of transcription 5B antibody; STA5B_ antibody; STAT5 antibody; Stat5b antibody; Transcription factor STAT5B antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P51692 Immunogen:Fusion protein of STAT5B Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:500-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 Background:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adµLt mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregµLation of the signaling pathways mediated by this protein may be the cause of the APLL. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:STAT5B Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism;Signal transduction