ELISA TRAF6 anti-

Quantity :50µL Clone Number: Aliases:E3 ubiquitin-protein ligase TRAF6 antibody; Interleukin 1 signal transducer antibody; Interleukin-1 signal transducer antibody; MGC 3310 antibody; MGC:3310 antibody; MGC3310 antibody; OTTHUMP00000232772 antibody; OTTHUMP00000232773 antibody; RING finger protein 85 antibody; RNF 85 antibody; RNF85 antibody; TNF receptor associated factor 6 antibody; TNF receptor-associated factor 6 antibody; TNF receptor-associated factor 6; E3 ubiquitin protein ligase antibody; TRAF 6 antibody; Traf6 antibody; TRAF6_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y4K3 Immunogen:Fusion protein of TRAF6 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 Background:The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjµgating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRAF6 Research Areas:Cancer;Cell biology;Immunology;Signal transduction