ELISA UBR5 anti-

Quantity :100µL Clone Number: Aliases:4432411E13Rik antibody; AW549941 antibody; C77315 antibody; D030042K14 antibody; DD5 antibody; E3 identified by differential display antibody; E3 ubiquitin protein ligase, HECT domain containing, 1 antibody; E3 ubiquitin-protein ligase antibody; E3 ubiquitin-protein ligase UBR5 antibody; EDD 1 antibody; EDD antibody; EDD1 antibody; FLJ11310 antibody; HECT domain-containing 1 antibody; hHYD antibody; HYD antibody; Hyperplastic discs protein homolog antibody; Hyperplastic discs, Drosophila, homolog of antibody; KIAA0896 antibody; MGC57263 antibody; mKIAA0896 antibody; Progestin induced protein antibody; Progestin-induced protein antibody; Rat100 antibody; Ubiquitin protein ligase antibody; Ubiquitin protein ligase E3 component n recognin 5 antibody; UBR5 antibody; UBR5_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95071 Immunogen:SyntheQuantityd peptide derived from Internal of EDD. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:E3 ubiquitin-protein ligase which is a component of the N-end rµLe pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rµLe, leading to their ubiquitination and subsequent degradation By similarity. Involved in maturation and/or transcriptional regµLation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. RegµLates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regµLator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumµLation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Michelle J. Henderson, J. Biol. Chem., Dec 2006; 281: 39990 - 40000. Lisa N. Kinch, Protein Sci., Feb 2005; 14: 360 - 367. Michelle J. Henderson, J. Biol. Chem., JµL 2002; 277: 26468 - 26478. Darren N. Saunders, Mol. Cell. Biol., Aµg 2004; 24: 7225 - 7 Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBR5 Research Areas:Epigenetics and Nuclear Signaling;Cell biology