ELISA TNFRSF11B Antibody, Biotin

Quantity :50µg Clone Number: Aliases:MGC29565 antibody; OCIF antibody; OPG antibody; Osteoclastogenesis inhibitory factor antibody; Osteoprotegerin antibody; PDB5 antibody; TNF receptor superfamily member 11b antibody; TNFRSF 11B antibody; TNFRSF11B antibody; TR 1 antibody; TR1 antibody; TR11B_ antibody; Tumor necrosis factor receptor superfamily member 11B antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00300 Immunogen:Recombinant Tumor necrosis factor receptor superfamily member 11B protein (22-235AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TNFRSF11B Research Areas:CardiovascµLar; Immunology; Metabolism; Signal transduction