ELISA TGFBR1 (Ab-165) anti-

Quantity :100µL Clone Number: Aliases:AAT 5 antibody; AAT5 antibody; Activin A receptor type II like kinase 53kDa antibody; Activin A receptor type II like kinase antibody; Activin A receptor type II like kinase, 53kD antibody; Activin A receptor type II like protein kinase of 53kD antibody; activin A receptor type II-like kinase, 53kDa antibody; activin A receptor type II-like protein kinase of 53kD antibody; Activin receptor like kinase 5 antibody; Activin receptor-like kinase 5 antibody; ACVRLK 4 antibody; ACVRLK4 antibody; ALK 5 antibody; ALK-5 antibody; ALK5 antibody; LDS1A antibody; LDS2A antibody; MSSE antibody; Serine/threonine protein kinase receptor R4 antibody; Serine/threonine-protein kinase receptor R4 antibody; SKR 4 antibody; SKR4 antibody; TbetaR I antibody; TbetaR-I antibody; TGF beta receptor type 1 antibody; TGF beta receptor type I antibody; TGF beta type I receptor antibody; TGF-beta receptor type I antibody; TGF-beta receptor type-1 antibody; TGF-beta type I receptor antibody; TGFBR 1 antibody; TGFBR1 antibody; TGFBR1 protein antibody; TGFR 1 antibody; TGFR-1 antibody; TGFR1 antibody; TGFR1_ antibody; Transforming growth factor beta receptor 1 antibody; Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD) antibody; Transforming growth factor beta receptor I antibody; transforming growth factor, beta receptor 1 antibody; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) antibody; Transforming growth factor-beta receptor type I antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P36897 Immunogen:SyntheQuantityd non-phosphopeptide derived from TGF ? Receptor I around the phosphorylation site of serine 165 (D-P-S(p)-L-D). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500 Background:Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regµLating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellµLar matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecµLes symmetrically bound to the cytokine dimer resµLts in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modµLates the transcription of the TGF-beta-regµLated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn resµLts in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regµLates epithelial to mesenchymal transition throµgh a SMAD-independent signaling pathway throµgh PARD6A phosphorylation and activation.Franzen P., Cell 75:681-692(1993).Vellucci V.F., Genomics 46:278-283(1997).Lynch M.A., Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TGFBR1 Research Areas:Cancer?CardiovascµLar;Metabolism;Signal transduction?Stem cells