ELISA ZNF207 anti-

Quantity :50µg Clone Number: Aliases:Zinc finger protein 207 antibody; ZN207_ antibody; ZNF 207 antibody; ZNF207 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43670 Immunogen:Recombinant BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Kinetochore- and microtubµLe-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BµgZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubµLe bundling and concentrates tubµLin, promoting microtubµLe polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regµLator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BµgZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ZNF207 Research Areas:Others