ELISA VIL1 anti-

Quantity :50µL Clone Number: Aliases:D2S1471 antibody; OTTHUMP00000164145 antibody; VIL antibody; VIL1 antibody; VILI_ antibody; Villin 1 antibody; Villin-1 antibody; Villin1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P09327 Immunogen:Recombinant Villin-1 protein (1-350AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Epithelial cell-specific Ca2+-regµLated actin-modifying protein that modµLates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. RegµLates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sµLfate (DSS) in the gastrointestinal epithelium. Appears to regµLate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:VIL1 Research Areas:Signal transduction