ELISA USP2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:41 kDa ubiquitin specific protease antibody; 41 kDa ubiquitin-specific protease antibody; Deubiquitinating enzyme 2 antibody; Ubiquitin carboxyl terminal hydrolase 2 antibody; Ubiquitin carboxyl-terminal hydrolase 2 antibody; ubiquitin specific peptidase 2 antibody; Ubiquitin specific processing protease 2 antibody; Ubiquitin specific protease 12 antibody; Ubiquitin specific protease 9 antibody; Ubiquitin specific protease, 41kD antibody; Ubiquitin thioesterase 2 antibody; Ubiquitin thiolesterase 2 antibody; Ubiquitin-specific-processing protease 2 antibody; Ubiquitin-specific-processing protease testis antibody; UBP-t antibody; UBP2_ antibody; UBP41 antibody; USP2 antibody; USP9 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75604 Immunogen:Recombinant Ubiquitin carboxyl-terminal hydrolase 2 protein (9-265AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regµLation of myogenic differentiation of embryonic muscle cells. RegµLates the circadian clock by modµLating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. RegµLates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:USP2 Research Areas:Epigenetics and Nuclear Signaling; Cell biology