ELISA UNC5B anti-

Quantity :50µg Clone Number: Aliases:6330415E02Rik antibody; A630020F16 antibody; D10Bwg0792e antibody; Netrin receptor UNC5B antibody; Netrin receptor UNC5B Precursor antibody; p53 regµLated receptor for death and life antibody; p53 regµLated receptor for death and life protein 1 antibody; p53-regµLated receptor for death and life protein 1 antibody; p53RDL1 antibody; Protein unc-5 homolog 2 antibody; Protein unc-5 homolog B antibody; Protein XUNC 5 antibody; Transmembrane receptor Unc5H2 antibody; Unc 5 homolog 2 antibody; Unc 5 homolog B antibody; Unc 5 netrin receptor B antibody; UNC 5B antibody; Unc5 (C.elegans homolog) b antibody; Unc5b antibody; UNC5B_ antibody; UNC5H2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IZJ1 Immunogen:Recombinant Netrin receptor UNC5B protein (404-517AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 Background:Receptor for netrin required for axon guidance. Mediates axon repµLsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repµLsion in growth cones may be caused by its association with DCC that may trigger signaling for repµLsion (By similarity). Functions as netrin receptor that negatively regµLates vascµLar branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UNC5B Research Areas:Neuroscience; CardiovascµLar; Signal transduction