ELISA ULK1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ATG 1 antibody; ATG1 antibody; ATG1 autophagy related 1 homolog antibody; ATG1A antibody; Autophagy related protein 1 homolog antibody; Autophagy-related protein 1 homolog antibody; FLJ38455 antibody; FLJ46475 antibody; hATG1 antibody; KIAA0722 antibody; Serine/threonine protein kinase µLK1 antibody; Serine/threonine protein kinase Unc51.1 antibody; Serine/threonine-protein kinase µLK1 antibody; µLK 1 antibody; µLK1 antibody; µLK1_ antibody; Unc 51 (C. elegans) like kinase 1 antibody; UNC 51 antibody; Unc 51 like kinase 1 antibody; Unc-51 like kinase 1 (C. elegans) antibody; Unc-51-like kinase 1 antibody; UNC51 antibody; UNC51; C. elegans; homolog of antibody; Unc51.1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75385 Immunogen:Recombinant Serine/threonine-protein kinase µLK1 protein (602-715AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regµLate the formation of autophagophores, the precursors of autophagosomes. Part of regµLatory feedback loops in autophagy: acts both as a downstream effector and negative regµLator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regµLator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regµLate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granµLe cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regµLate autophagy (PubMed:25040165). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:µLK1 Research Areas:Neuroscience; CardiovascµLar; Metabolism; Signal transduction