ELISA UBE3A anti-

Quantity :50µg Clone Number: Aliases:ANCR antibody; Angelman syndrome antibody; AS antibody; CTCL tumor antigen se37 2 antibody; CTCL tumor antigen se37-2 antibody; E6 AP antibody; E6AP antibody; E6AP ubiquitin protein ligase antibody; E6AP ubiquitin-protein ligase antibody; EPVE6AP antibody; FLJ26981 antibody; HECT-type ubiquitin transferase E3A antibody; HPVE6A antibody; papilloma virus E6 associated protein Angelman syndrome antibody; papilloma virus E6 associated protein antibody; papillomavirus E6-associated protein antibody; NY REN 54 antigen antibody; Oncogenic protein associated protein E6 AP antibody; Oncogenic protein associated protein E6AP antibody; Oncogenic protein-associated protein E6-AP antibody; Renal carcinoma antigen NY REN 54 antibody; Renal carcinoma antigen NY-REN-54 antibody; UBE 3A antibody; Ube3a antibody; UBE3A protein antibody; UBE3A_ antibody; Ubiquitin protein ligase E3A antibody; Ubiquitin-protein ligase E3A antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q05086 Immunogen:Recombinant Ubiquitin-protein ligase E3A protein (83-234AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjµgating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PmL tumor suppressor, and the cell cycle regµLator CDKN1B. Catalyzes the high-risk papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellµLar quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regµLation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBE3A Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cell biology