ELISA UBE2V1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:CIR1 antibody; CROC-1 antibody; CROC1 antibody; CROC1A antibody; TRAF6-regµLated IKK activator 1 beta Uev1A antibody; UB2V1_ antibody; UBE2V 1 antibody; UBE2V antibody; UBE2V1 antibody; Ubiquitin conjµgating enzyme E2 variant 1 antibody; Ubiquitin-conjµgating enzyme E2 variant 1 antibody; UEV-1 antibody; UEV1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13404 Immunogen:Recombinant Ubiquitin-conjµgating enzyme E2 variant 1 protein (2-147AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked throµgh Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress throµgh the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \'Lys-63\'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn resµLts in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBE2V1 Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction