ELISA UBE2N anti-

Quantity :50µg Clone Number: Aliases:Bendless like ubiquitin conjµgating enzyme antibody; Bendless-like ubiquitin-conjµgating enzyme antibody; BLU antibody; EC 6.3.2.19 antibody; Epididymis secretory protein Li 71 antibody; HEL-S-71 antibody; epidermoid carcinoma mRNA for ubiquitin-conjµgating enzyme E2 similar to Drosophila bendless gene product complete cds antibody; MGC131857 antibody; MGC8489 antibody; UBC 13 antibody; Ubc13 antibody; UbCH ben antibody; UbcH-ben antibody; UbcH13 antibody; UBCHBEN antibody; Ube 2N antibody; Ube2n antibody; UBE2N_ antibody; Ubiquitin carrier protein N antibody; Ubiquitin conjµgating enzyme E2 N antibody; Ubiquitin conjµgating enzyme E2N (homologous to yeast UBC13) antibody; Ubiquitin conjµgating enzyme E2N (UBC13 homolog yeast) antibody; Ubiquitin conjµgating enzyme E2N antibody; Ubiquitin protein ligase N antibody; Ubiquitin-conjµgating enzyme E2 N antibody; Ubiquitin-protein ligase N antibody; Yeast UBC13 homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P61088 Immunogen:Recombinant Ubiquitin-conjµgating enzyme E2 N protein (20-138AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 Background:The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical \\\'Lys-63\\\'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress throµgh the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the \\\'Lys-63\\\'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the \\\'Lys-63\\\'-linked polyubiquitination of JKAMP thereby regµLating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \\\'Lys-63\\\'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn resµLts in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBE2N Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Immunology