ELISA U2AF2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:hU2AF(65) antibody; hU2AF65 antibody; Splicing factor U2AF 65 kDa subunit antibody; U2 (RNU2) small nuclear RNA auxiliary factor 2 antibody; U2 auxiliary factor 65 kDa subunit antibody; U2 small nuclear ribonucleoprotein auxiliary factor (65kD) antibody; U2 small nuclear RNA auxiliary factor 2 antibody; U2 snRNP auxiliary factor large subunit antibody; U2af2 antibody; U2AF2_ antibody; U2AF65 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P26368 Immunogen:Recombinant Splicing factor U2AF 65 kDa subunit protein (124-246AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. RegµLates the TNNT2 exon 5 inclusion throµgh competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:U2AF2 Research Areas:Epigenetics and Nuclear Signaling