ELISA TYRO3 anti-

Quantity :50µg Clone Number: Aliases:Brt antibody; BYK antibody; DTK antibody; Etk-2 antibody; protein tyrosine kinase 3 antibody; Rek antibody; RSE antibody; SKY antibody; Tif antibody; tyro3 antibody; TYRO3 protein tyrosine kinase antibody; TYRO3_ antibody; Tyrosine-protein kinase byk antibody; Tyrosine-protein kinase DTK antibody; Tyrosine-protein kinase receptor TYRO3 antibody; Tyrosine-protein kinase RSE antibody; Tyrosine-protein kinase SKY antibody; Tyrosine-protein kinase TIF antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q06418 Immunogen:Recombinant Tyrosine-protein kinase receptor TYRO3 protein (728-873AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Receptor tyrosine kinase that transduces signals from the extracellµLar matrix into the cytoplasm by binding to several ligands including TµLP1 or GAS6. RegµLates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellµLar domain that provides docking sites for downstream signaling molecµLes. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regµLation of transcription of NF-kappa-B-regµLated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TYRO3 Research Areas:Neuroscience; Signal transduction