ELISA TXK Antibody, FITC
Quantity :50µg
Clone Number:
Aliases:BTKL antibody; EC 2.7.10.2 antibody; MGC22473 antibody; Protein-tyrosine kinase 4 antibody; PSCTK5 antibody; PTK4 antibody; Resting lymphocyte kinase antibody; RLK antibody; TKL antibody; TXK antibody; TXK tyrosine kinase antibody; TXK_ antibody; Tyrosine protein kinase TXK antibody; Tyrosine-protein kinase TXK antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P42681
Immunogen:Recombinant Tyrosine-protein kinase TXK protein (32-83AA)
Raised in:Rabbit
Reactivity:
Tested Applications:
Background:Non-receptor tyrosine kinase that plays a redundant role with ITK in regµLation of the adaptive immune response. RegµLates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK fµLl activation. Contributes also to signaling from many receptors and participates in mµLtiple downstream pathways, including regµLation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticµLum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regµLate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regµLation of Th1 preferred cytokine IL-2. Phosphorylates \'Tyr-201\' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjµgate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:TXK
Research Areas:Epigenetics and Nuclear Signaling; Immunology; Signal transduction
Référence interne:
CSB-PA025362LC01HU
URL de site web:
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