ELISA TXK Antibody, FITC

Quantity :50µg Clone Number: Aliases:BTKL antibody; EC 2.7.10.2 antibody; MGC22473 antibody; Protein-tyrosine kinase 4 antibody; PSCTK5 antibody; PTK4 antibody; Resting lymphocyte kinase antibody; RLK antibody; TKL antibody; TXK antibody; TXK tyrosine kinase antibody; TXK_ antibody; Tyrosine protein kinase TXK antibody; Tyrosine-protein kinase TXK antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P42681 Immunogen:Recombinant Tyrosine-protein kinase TXK protein (32-83AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Non-receptor tyrosine kinase that plays a redundant role with ITK in regµLation of the adaptive immune response. RegµLates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK fµLl activation. Contributes also to signaling from many receptors and participates in mµLtiple downstream pathways, including regµLation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticµLum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regµLate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regµLation of Th1 preferred cytokine IL-2. Phosphorylates \'Tyr-201\' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TXK Research Areas:Epigenetics and Nuclear Signaling; Immunology; Signal transduction