ELISA TNKS Antibody, HRP

Quantity :50µg Clone Number: Aliases:ADP-ribosyltransferase diphtheria toxin-like 5 antibody; OTTHUMP00000115550 antibody; OTTHUMP00000224675 antibody; PARP 5a antibody; PARP5A antibody; PARPL antibody; pART5 antibody; Poly [ADP-ribose] polymerase 5A antibody; TANK 1 antibody; TANK1 antibody; Tankyrase 1 antibody; Tankyrase I antibody; Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase antibody; Tankyrase-1 antibody; Tankyrase1 antibody; TankyraseI antibody; TIN 1 antibody; TIN1 antibody; TINF 1 antibody; TINF1 antibody; TNKS 1 antibody; TNKS antibody; TNKS-1 antibody; TNKS1 antibody; TNKS1_ antibody; TRF1 interacting ankyrin related ADP ribose polymerase antibody; TRF1-interacting ankyrin-related ADP-ribose polymerase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95271 Immunogen:Recombinant Tankyrase-1 protein (35-130AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regµLation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regµLate vesicle trafficking and modµLate the subcellµLar distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly throµgh PARsylation of NUMA1. StimµLates 26S proteasome activity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TNKS Research Areas:Epigenetics and Nuclear Signaling