ELISA TNFSF11 Antibody, HRP

Quantity :50µg Clone Number: Aliases:CD254 antibody; hRANKL2 antibody; ODF antibody; OPGL antibody; OPTB2 antibody; Osteoclast differentiation factor antibody; Osteoprotegerin ligand antibody; RANKL antibody; Receptor activator of NF-kappa-B ligand antibody; Receptor activator of nuclear factor kappa B ligand antibody; Receptor activator of nuclear factor kappa-B ligand antibody; sOdf antibody; soluble form antibody; TNF-related activation-induced cytokine antibody; TNF11_ antibody; Tnfsf11 antibody; TRANCE antibody; Tumor necrosis factor (ligand) superfamily member 11 antibody; Tumor necrosis factor ligand superfamily member 11 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14788 Immunogen:Recombinant Tumor necrosis factor ligand superfamily member 11 protein (73-306AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Aµgments the ability of dendritic cells to stimµLate naive T-cell proliferation. May be an important regµLator of interactions between T-cells and dendritic cells and may play a role in the regµLation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating mµLtiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellµLar concentration of Ca (2+) resµLting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TNFSF11 Research Areas:CardiovascµLar; Immunology