ELISA TMEM173 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:endoplasmic reticµLum IFN stimµLator antibody; Endoplasmic reticµLum interferon stimµLator antibody; ERIS antibody; FLJ38577 antibody; hMITA antibody; hSTING antibody; Mediator of IRF3 activation antibody; MITA antibody; Mitochondrial mediator of IRF3 activation antibody; MPYS antibody; N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody; NET23 antibody; StimµLator of interferon genes antibody; StimµLator of interferon genes protein antibody; STING antibody; TM173_ antibody; Tmem173 antibody; Transmembrane protein 173 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86WV6 Immunogen:Recombinant StimµLator of interferon genes protein (207-379AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellµLar signal-regµLated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to herpes simplex virus 1 (HHV-1) infection. Exhibits 2\',3\' phosphodiester linkage-specific ligand recognition. Can bind both 2\'-3\' linked cGAMP and 3\'-3\' linked cGAMP but is preferentially activated by 2\'-3\' linked cGAMP (PubMed:26300263). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TMEM173 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Immunology; Signal transduction