ELISA TARDBP Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ALS10 antibody; OTTHUMP00000002171 antibody; OTTHUMP00000002172 antibody; OTTHUMP00000002173 antibody; TADBP_ antibody; TAR DNA binding protein 43 antibody; TAR DNA binding protein antibody; TAR DNA-binding protein 43 antibody; TARDBP antibody; TDP 43 antibody; TDP-43 antibody; TDP43 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13148 Immunogen:Recombinant TAR DNA-binding protein 43 protein (1-396AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:DNA and RNA-binding protein which regµLates transcription and splicing. Involved in the regµLation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the µg repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resµLting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecµLar weight neurofilament (NFL) mRNA throµgh a direct interaction with the 3' UTR. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TARDBP Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Microbiology